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زیست شناسی::
پیرایش پس از ترجمه
Fourth, S. cerevisiae is capable of carrying out many posttranslational modifications.
Similar to yeast, filamentous fungi can grow rapidly on inexpensive media, secrete large amounts of proteins, process eukaryotic mRNA, and carry out many posttranslational modifications.
Fur thermore, because of the similarity of posttranslational modification systems between insects and mammals, it was thought that the recombinant pro tein would mimic closely, if not precisely, the authentic form of the original protein.
Although many heterologous proteins have been suc cessfully synthesized in prokaryotic host cells, some proteins require eukaryotespecific posttranslational modifications, such as glycosylation, to be functional.
Many therapeutic proteins that require a full comple ment of posttranslational modifications are now produced in cultured mammalian cells, such as CHO cells.
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